Nfl All Time Yards Rushing 2025 List. Between this season and the 2025 season, derrick henry rushed for the most yards, with 1,120 yards. Between the 2020 and 2025 seasons, derrick henry rushed for the most yards, with 6,789 yards.

251 rows view current leaderboard. Taylor, a member of the pride of the jaguars, ranks no.